Endocrine Abstracts

Objective: The goal of this study is to evaluate the relationship between levels of adiponectin and vaspin, adiponectin/vaspin (A/V) ratio and metabolic syndrome, degree of adiposity, and insulin resistance (IR), as well as their correlation with metabolic variables.Methods: Two hundred sixty patients with newly diagnosed type 2 diabetes (126 male, 134 female) were enrolled. Patients were grouped based on degree of adiposity, IR assessment (homeostasis m...

Objective: To investigate the influence of vitamin E (VE) and selenium (Se) on apoptosis of human thyrocyte induced by H2O2.Methods: The human thyroid epithelium cells (TEC) from normal para-adenoma tissues of patients with thyroid adenoma resection were cultured. In prevention groups, vitamin E (50 μmol/l), selenium (10–7 mol/l) or serum-free medium was respectively added into thyrocytes of monolayer culture before H...

Multiple endocrine neoplasia type 1 (MEN1) is an inherited tumour syndrome characterized by the development of tumours of the parathyroid, anterior pituitary and pancreatic islets, etc. Heterozygous germ line mutations of MEN1 gene are responsible for the onset of MEN1. Here We reported totally 87 patients from 24 unrelated Chinese families associated with MEN1 and identified five novel mutations and several previously reported mutations. Furthermore, we detected a loss of het...

Cancer cells have shown an overexpressed fructose transporter GLUT5 and preferential utilization of fructose as compared to glucose, implicating that a fructose-based analogue would be a useful target for diagnosis and treatment of cancer. We have successfully synthesized the fructose conjugated-gefitinib compounds {N-[4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-7-methoxy-quinazolin-6-yl]-4- [N-methyl-N-(1-deoxy-1-fructosyl)]aminobutanamide}, and examined its antitumor effic...